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Regional differences in colorectal cancer incidence, stage, and subsite among American Indians and Alaska Natives, 1999-2004

TitleRegional differences in colorectal cancer incidence, stage, and subsite among American Indians and Alaska Natives, 1999-2004
Publication TypeJournal Article
Year of Publication2008
AuthorsPerdue, DG, Perkins, C, Jackson-Thompson, J, Coughlin, SS, Ahmed, F, Haverkamp, DS, Jim, MA
Date PublishedSep 1
ISBN Number0008-543X (Print)<br/>0008-543X (Linking)
Accession Number18720388
KeywordsAdenocarcinoma/ethnology/pathology, Adolescent, Adult, Aged, Aged, 80 and Over, Alaska/epidemiology, Child, Child, Preschool, Colorectal Neoplasms/ ethnology/ pathology, Continental Population Groups/statistics & numerical data, Female, Geography, Humans, Incidence, Indians, North American/ statistics & numerical data, Infant, Infant, Newborn, Inuits/ statistics & numerical data, Male, Middle Aged, Neoplasm Staging, United States/epidemiology
AbstractBACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality for American Indians and Alaska Natives (AI/ANs), but misclassification of race causes underestimates of disease burden. METHODS: The authors compared regional differences in CRC incidence, stage at diagnosis, and anatomic distribution between AI/ANs and non-Hispanic whites (NHWs). To reduce misclassification, data from the National Program of Cancer Registries; the Surveillance, Epidemiology, and End Results Program; and the Indian Health Service (IHS) were linked. The analysis was limited to the 56% of AI/AN who live in IHS Contract Health Service Delivery Areas. RESULTS: From 1999 to 2004, the overall incidence rate (per 100,000 persons per year) of CRC was 9% lower in the AI/AN population (46.3) than in the NHW population (50.8). However, AI/AN CRC incidence rates varied nearly 5-fold regionally, from 21 in the Southwest to 102.6 in Alaska. Compared with NHW rates, AI/AN rates were significantly higher in Alaska (rate ratio [RR], 2.03), the Northern Plains (RR, 1.39), and the Southern Plains (RR, 1.16) but were lower in the Pacific Coast (RR, 0.80), the East (RR, 0.65), and the Southwest (RR, 0.45). AI/ANs were diagnosed more often with advanced CRC than with localized CRC (RR, 1.92) compared with NHWs (RR, 1.48). Females more often had proximal CRC among both the AI/AN population (females, 40.1%; males, 33.5%) and the NHW population (females, 50.1%; males, 40.3%), although AI/ANs had a higher proportion of distal cancers overall. CONCLUSIONS: CRC incidence rates in AI/AN populations varied dramatically between regions. Efforts are needed to make CRC screening a priority, overcome barriers to endoscopic screening, and to engage AI/AN communities in culturally appropriate ways to participate in prevention and early detection programs.
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