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Prevalence of high-risk HPV types and abnormal cervical cytology in American Indian/Alaska Native women, 2003-2005

TitlePrevalence of high-risk HPV types and abnormal cervical cytology in American Indian/Alaska Native women, 2003-2005
Publication TypeJournal Article
Year of Publication2011
AuthorsAlfonsi, GA, Datta, SD, Mickiewicz, T, Koutsky, LA, Ghanem, K, Hagensee, M, Kerndt, P, Hsu, K, Weinstock, H, Shlay, JC
JournalPublic Health RepPublic Health Rep
Volume126
Pagination330-7
Date PublishedMay-Jun
ISBN Number0033-3549 (Print)<br/>0033-3549 (Linking)
Accession Number21553660
KeywordsAdolescent, Adult, Aged, Cervix Uteri/pathology/virology, Chi-Square Distribution, Continental Population Groups/statistics & numerical data, Cross-Sectional Studies, Female, Human papillomavirus 16/isolation & purification, Human papillomavirus 18/isolation & purification, Humans, Indians, North American/ statistics & numerical data, Inuits/ statistics & numerical data, Middle Aged, Papanicolaou Test, Papillomavirus Infections/ diagnosis/epidemiology/ ethnology/virology, Prevalence, Risk Factors, Tumor Virus Infections/ diagnosis/epidemiology/ ethnology/virology, United States/epidemiology, Vaginal Smears
AbstractOBJECTIVES; We described prevalence estimates of high-risk human papillomavirus (HR-HPV), HPV types 16 and 18, and abnormal Papanicolaou (Pap) smear tests among American Indian/Alaska Native (AI/AN) women compared with women of other races/ethnicities. METHODS: A total of 9,706 women presenting for cervical screening in a sentinel network of 26 clinics (sexually transmitted disease, family planning, and primary care) received Pap smears and HR-HPV type-specific testing. We compared characteristics of 291 women self-identified as AI/AN with other racial/ethnic minority groups. RESULTS: In our population, AI/AN and non-Hispanic white (NHW) women had similar age- and clinic-adjusted prevalences of HR-HPV (29.1%, 95% confidence interval [CI] 23.9, 34.3 for AI/AN women vs. 25.8%, 95% CI 24.4, 27.2 for NHW women), HPV 16 and 18 (6.7%, 95% CI 3.9, 9.6 for AI/AN women vs. 8.8%, 95% CI 7.9, 9.7 for NHW women), and abnormal Pap smear test results (16%, 95% CI 11.7, 20.3 for AI/AN women vs. 14.9%, 95% CI 13.7, 16.0 for NHW women). AI/AN women had a higher prevalence of HR-HPV than Hispanic women, and a similar prevalence of HPV 16 and 18 as compared with Hispanic and African American women. CONCLUSIONS: We could not demonstrate differences in the prevalence of HR-HPV, HPV 16 and 18, or abnormal Pap smear test results between AI/AN and NHW women. This finding should improve confidence in the benefit of HPV vaccine and Pap smear screening in the AI/AN population as an effective strategy to reduce rates of cervical cancer.
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