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Lifestyle and the Risk of Dementia in Japanese-American Men

TitleLifestyle and the Risk of Dementia in Japanese-American Men
Publication TypeJournal Article
Year of Publication2012
AuthorsGelber, RP, Petrovitch, H, Masaki, KH, Abbott, RD, Ross, GWebster, Launer, LJ, White, LR
JournalJournal of the American Geriatrics SocietyJournal of the American Geriatrics Society
Volume60
Pagination118-123
ISBN Number0002-8614
KeywordsAged, Aged, 80 and Over, Analysis of Covariance, Case Control Studies, Clinical Assessment Tools, Confidence Intervals, Data Analysis Software, Dementia -- Diagnosis, Dementia -- Ethnology, Dementia -- Risk Factors -- In Old Age, Diet, Funding Source, Hawaii, Health Behavior -- In Middle Age, Human, Japanese, Life Style, Logistic Regression, Male, Middle Age, Odds Ratio, Prospective Studies, Risk Assessment
AbstractObjectives To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. Design Case-control study nested in a prospective cohort. Setting The Honolulu-Asia Aging Study, Oahu, Hawaii. Participants Three thousand four hundred sixty-eight Japanese- American men (mean age 52 in 1965-1968) examined for dementia 25 years later. Measurements Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m2, physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios ( ORs) and 95% confidence intervals ( CIs) for developing overall dementia, Alzheimer's disease ( AD), and vascular dementia ( VaD), adjusting for potential confounders. Results Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia ( OR = 1.87, 95% CI = 1.26-2.77; BMI > 25.0 vs 2). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia ( OR = 0.36, 95% CI = 0.15-0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone. Conclusion Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life.
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