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The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: an analysis of the Survival, Epidemiology, and End Results database

TitleThe influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: an analysis of the Survival, Epidemiology, and End Results database
Publication TypeJournal Article
Year of Publication2012
AuthorsSaeed, AM, Toonkel, R, Glassberg, MK, Nguyen, D, Hu, JJ, Zimmers, TA, Robbins, DJ, Koniaris, LG, Lally, BE
JournalCancerCancer
Volume118
Pagination4495-501
Date PublishedSep 15
ISBN Number1097-0142 (Electronic)<br/>0008-543X (Linking)
Accession Number22528551
KeywordsAfrican Americans, Aged, Aged, 80 and Over, Carcinoma, Non-Small-Cell Lung/ ethnology/mortality/pathology, Female, Hispanic Americans, Humans, Lung Neoplasms/ ethnology/mortality/pathology, Male, Middle Aged, Prognosis, SEER Program, United States
AbstractBACKGROUND: Most studies exploring ethnic/racial disparities in nonsmall cell lung cancer (NSCLC) compare black patients with whites. Currently, the effect of Hispanic ethnicity on the overall survival of NSCLC is poorly understood. Therefore, the authors carried out a large-scale, population-based analysis using the Surveillance, Epidemiology, and End Results (SEER) data base to determine the impact of Hispanic ethnicity the survival of patients with NSCLC. METHODS: The authors identified 172,398 adult patients with pathologically confirmed NSCLC from the SEER data base who were diagnosed between 1988 and 2007. A multivariate Cox proportional hazards regression analysis was used to determine the impact of race/ethnicity on overall survival. Pair-wise comparisons were used to determine whether Hispanic ethnicity influenced NSCLC histology or stage at diagnosis. RESULTS: Compared with non-Hispanic white patients, Hispanic white patients had a statistically significant better overall survival (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.83-0.87), and black patients had worse survival (HR, 1.091; 95% CI, 1.072-1.109). Within the bronchioalveolar carcinoma (BAC) subtype, Hispanic-white patients tend to be over represented (8.1% Hispanic whites vs 5.5% non-Hispanic whites vs 3.7% blacks; P