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Impact of androgen deprivation therapy on racial/ethnic disparities in the survival of older men treated for locoregional prostate cancer

TitleImpact of androgen deprivation therapy on racial/ethnic disparities in the survival of older men treated for locoregional prostate cancer
Publication TypeJournal Article
Year of Publication2009
AuthorsHolmes, Jr., L, Chan, W, Jiang, Z, Ward, D, Essien, EJ, Du, XL
JournalCancer ControlCancer Control
Volume16
Pagination176-85
Date PublishedApr
ISBN Number1526-2359 (Electronic)<br/>1073-2748 (Linking)
Accession Number19337204
KeywordsAfrican Americans, Aged, Aged, 80 and Over, Androgen Antagonists/ therapeutic use, Antineoplastic Agents, Hormonal/ therapeutic use, Asian Continental Ancestry Group, Combined Modality Therapy, Comorbidity, European Continental Ancestry Group, Hispanic Americans, Humans, Kaplan-Meier Estimate, Male, Proportional Hazards Models, Prostatectomy, Prostatic Neoplasms/ drug therapy/ ethnology/ mortality, Radiotherapy, SEER Program
AbstractBACKGROUND: Racial disparities persist in prostate cancer (CaP) treatment and survival, but disparities in androgen deprivation therapy (ADT) and the degree to which it affects racial differences in survival remains to be fully assessed. METHODS: Using the Surveillance, Epidemiology and End Results-Medicare linked data, we examined a large cohort of men (N = 64,475) diagnosed with locoregional CaP during 1992 to 1999 and followed through 2003. The effects of ADT and race on survival were analyzed using a Cox proportional hazards model. RESULTS: The receipt of ADT was significantly lower in African Americans (24%) relative to Caucasians (27%), Asians (34%), and Hispanics (28.7%) (P
Ethno Med: