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Fasting total homocysteine (tHcy) concentration and mortality in older Mexican Americans

TitleFasting total homocysteine (tHcy) concentration and mortality in older Mexican Americans
Publication TypeJournal Article
Year of Publication2008
AuthorsV. Lopez, C, Haan, MN, Aiello, AE, Ghosh, D
JournalJ Nutr Health AgingJ Nutr Health Aging
Date PublishedDec
ISBN Number1760-4788 (Electronic)<br/>1279-7707 (Linking)
Accession Number19043642
KeywordsAged, Aged, 80 and Over, Biological Markers/blood, California/epidemiology, Cardiovascular Diseases/ethnology/ mortality, Female, Homocysteine/ blood, Humans, Longitudinal Studies, Male, Mexican Americans, Mexico/ethnology, Middle Aged, Proportional Hazards Models
AbstractOBJECTIVES: This study examines the association between tHcy on cardiovascular and noncardiovascular mortality. DESIGN: Longitudinal study of 1,633 Mexican Americans age>60 years recruited in 1998. SETTING: Sacramento, California. MEASUREMENTS: Cox proportional models were used to estimate the effects of tHcy on mortality rate in the total sample and in a subgroup of subjects without a history of cardiovascular disease at baseline. RESULTS: About half of the cohort was born in Mexico. Among Mexican-born participants, high tHcy (>11.0 micromol/L) was associated with a higher rate of cardiovascular mortality compared to those with low tHcy concentration