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ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes

TitleENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
Publication TypeJournal Article
Year of Publication2005
AuthorsAbate, N, Chandalia, M, Satija, P, Adams-Huet, B, Grundy, SM, Sandeep, S, Radha, V, Deepa, R, Mohan, V
Date PublishedApr
ISBN Number0012-1797 (Print)<br/>0012-1797 (Linking)
Accession Number15793263
KeywordsAdult, Asian Continental Ancestry Group/genetics, Diabetes Mellitus, Type 2/ genetics, Environment, European Continental Ancestry Group/genetics, Female, Genetic Predisposition to Disease, Genotype, Humans, India, Male, Middle Aged, Obesity/genetics, Phenotype, Phosphoric Diester Hydrolases/ genetics, Polymorphism, Genetic, Pyrophosphatases/ genetics, Risk Factors, Texas
AbstractGenetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three populations that differ in susceptibility to diabetes and environmental exposure. The three cohorts included 679 nonmigrant South Asians living in Chennai, India (223 with type 2 diabetes); 1,083 migrant South Asians living in Dallas, Texas (121 with type 2 diabetes); and 858 nonmigrant Caucasians living in Dallas, Texas (141 with type 2 diabetes). Patients with type 2 diabetes were included in these cohorts if they had diabetes onset before the age of 60 years. The prevalence of subjects carrying the polymorphic ENPP1 121Q allele was 25% in the nondiabetic group and 34% in the diabetic group of South Asians living in Chennai (P = 0.01). The prevalence in the nondiabetic and diabetic groups were 33 and 45% (P = 0.01) for the South Asians living in Dallas and 26 and 39% (P = 0.003) for the Caucasians. Although further replication studies are necessary to test the validity of the described genotype-phenotype relationship, our study supports the hypothesis that ENPP1 121Q predicts genetic susceptibility to type 2 diabetes in both South Asians and Caucasians.