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The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults

TitleThe effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults
Publication TypeJournal Article
Year of Publication2013
AuthorsMiernyk, K, Bruden, D, Zanis, C, McMahon, B, Sacco, F, Hennessy, T, Parkinson, A, Bruce, M
JournalHelicobacterHelicobacter
Volume18
Pagination222-8
Date PublishedJun
ISBN Number1523-5378 (Electronic)<br/>1083-4389 (Linking)
Accession Number23316928
KeywordsAdult, Alaska, Anemia, Iron-Deficiency/complications/drug therapy/ epidemiology/ etiology, Anti-Bacterial Agents/therapeutic use, Female, Ferritins/blood, Helicobacter Infections/ complications/drug therapy/ epidemiology/microbiology, Helicobacter pylori/ isolation & purification, Humans, Indians, North American, Inuits, Iron/blood/deficiency/ metabolism, Male, Middle Aged, Urban Population
AbstractBACKGROUND: Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency. METHODS: Alaska Native adults undergoing esophagogastroduodenoscopy had sera collected and a (13) C urea breath test (UBT) was performed. Those H. pylori positive were treated with an antibiotic regimen; those who tested negative 2 months after treatment were evaluated at 4, 6, 12, and 24 months by UBT and serum ferritin with an immunoradiometric assay. We excluded persons from further analysis if they were prescribed iron by their provider. RESULTS: We measured serum ferritin for 241 persons; 121/241 were H. pylori positive. The geometric mean ferritin (GMF) for persons with and without H. pylori infection was 37 mug/L and 50 mug/L, respectively (p = .04). At enrollment, 19/121 H. pylori-positive persons had iron deficiency compared with 8/120 H. pylori negative (p = .02). Among 66 persons tested at 24 months, the GMF was higher at 24 months (49.6 mug/L) versus enrollment (36.5 mug/L; p = .02). Six of 11 persons with iron deficiency at enrollment no longer had iron deficiency and had a higher GMF (p = .02) 24 months after treatment. CONCLUSIONS: H. pylori infection was correlated with lower serum ferritin and iron deficiency. After H. pylori eradication, serum ferritin increased and approximately half of persons resolved their iron deficiency. Testing for H. pylori infection and subsequent treatment of those positive could be considered in persons with unexplained iron deficiency.
Ethno Med: