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Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese americans

TitleChange in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese americans
Publication TypeJournal Article
Year of Publication2013
AuthorsWander, PL, Boyko, EJ, Leonetti, DL, McNeely, MJ, Kahn, SE, Fujimoto, WY
JournalDiabetes CareDiabetes Care
Volume36
Pagination289-293
ISBN Number0149-5992
KeywordsAdipose Tissue, Adipose Tissue Distribution -- Physiology, Adult, Aged, Asians, Diabetes Mellitus, Type 2 -- Epidemiology, Female, Human, Male, Middle Age
AbstractOBJECTIVE -Visceral adiposity is an important risk factor for cardiovascular disease and type 2 diabetes. We sought to determine whether change in intraabdominal fat area (IAF) over time predicts subsequent development of diabetes. RESEARCH DESIGN AND METHODS -We followed up 436 nondiabetic Japanese-American subjects (mean age 51.9 years, mean BMI 24.2 kg/m(2), 54% male) for development of diabetes. We fit a logistic regression model to examine the association over a 10-year follow-up between change in IAF at 5-year follow-up and other fat areas (measured by computed tomography) and development of incident diabetes, adjusted for age, sex, family history of diabetes in a first-degree relative, second-generation versus third-generation Japanese American (Nisei vs. Sansei), baseline IAF, BMI, weight change over time, smoking status, physical activity level, and subcutaneous fat (SCF) depot areas. RESULTS -Cumulative incidence of diabetes was 20.4% at 10 years. Mean change in IAF was 10.9 cm(2). An increase of 1 SD in IAF was associated with a 1.65-fold increase in the odds of diabetes over 10 years (OR = 1.65, 95% CI 1.21-2.25) after adjusting for the above covariates. This association was also independent of changes in thoracic, thigh, and abdominal SCF, as well as change in weight. CONCLUSIONS -We conclude that baseline IAF and accumulation of fat in this area over time are independent predictors of the development of type 2 diabetes in Japanese Americans.
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