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Cardiovascular risk score, cognitive decline, and dementia in older Mexican Americans: the role of sex and education

TitleCardiovascular risk score, cognitive decline, and dementia in older Mexican Americans: the role of sex and education
Publication TypeJournal Article
Year of Publication2013
AuthorsA. Hazzouri, ZAl, Haan, MN, Neuhaus, JM, Pletcher, M, Peralta, CA, Lopez, L, Stable, EJPerez
JournalJ Am Heart AssocJ Am Heart Assoc
Volume2
Paginatione004978
Date PublishedApr
ISBN Number2047-9980 (Electronic)<br/>2047-9980 (Linking)
Accession Number23608609
KeywordsAged, Aged, 80 and Over, Aging, Cardiovascular Diseases/ ethnology, Cognition Disorders/ ethnology, Cohort Studies, Dementia/ ethnology, Educational Status, Female, Humans, Incidence, Male, Mexican Americans, Middle Aged, Prospective Studies, Risk Factors, Sex Distribution, Social Class, United States/epidemiology
AbstractBACKGROUND: The purpose of this study was to examine the associations of cardiovascular disease (CVD) risk with cognitive decline and incidence of dementia and cognitive impairment but not dementia (CIND) and the role of education as a modifier of these effects. METHODS AND RESULTS: One thousand one hundred sixteen Mexican American elderly were followed annually in the Sacramento Area Latino Study on Aging. Our sex-specific 10-year CVD risk score included baseline age, systolic blood pressure, total cholesterol, high-density lipoprotein, smoking, body mass index, and diabetes. From adjusted linear mixed models, errors on the Modified Mini-Mental State Exam (3MSE) were annually 0.41% lower for women at the 25th percentile of CVD risk, 0.11% higher at the 50th percentile, and 0.83% higher at the 75th percentile (P value of CVDriskxtime