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Cardiovascular disease prevalence and its relation to risk factors in Alaska Eskimos

TitleCardiovascular disease prevalence and its relation to risk factors in Alaska Eskimos
Publication TypeJournal Article
Year of Publication2010
AuthorsHoward, BV, Comuzzie, A, Devereux, RB, Ebbesson, SO, Fabsitz, RR, Howard, WJ, Laston, S, MacCluer, JW, Silverman, A, Umans, JG, Wang, H, Weissman, NJ, Wenger, CR
JournalNutr Metab Cardiovasc DisNutr Metab Cardiovasc Dis
Date PublishedJun
ISBN Number1590-3729 (Electronic)<br/>0939-4753 (Linking)
Accession Number19800772
KeywordsAlaska/epidemiology, Cardiovascular Diseases/ epidemiology/etiology, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Cross-Sectional Studies, Fatty Acids, Omega-3/administration & dosage, Female, Humans, Inuits, Male, Middle Aged, Prevalence, Risk Factors, Sex Characteristics
AbstractBACKGROUND AND AIMS: Although Eskimos were thought to be protected from cardiovascular disease (CVD), state health data show a large proportion of deaths from CVD, despite traditional lifestyles and high omega-3 fatty acid intake. This article explores CVD prevalence and its relation to risk factors in Alaska Eskimos. METHODS AND RESULTS: A population-based cohort of 499 Alaska Eskimos > age 45 from the Norton Sound region was examined in 2000-2004 for CVD and associated risk factors as part of the Genetics of Coronary Artery Disease in Alaska Natives study. CVD and atherosclerosis were evaluated and adjudicated using standardized methods. Average age was 58 years; diabetes prevalence was low and high-density lipoprotein cholesterol (HDL-C) concentrations were high, but a large proportion smoked and had high pathogen burden. CVD was higher in men (12.6%) than in women (5.3%) (prevalence ratio 2.4, CI 1.3-4.4). Rates of stroke (6.1% in men, 1.8% in women) were similar to those for coronary heart disease (CHD) (6.1% men, 2.5% women). MI prevalence was low in both genders (1.9% and 0.7%). CVD was higher in men and in those >60 years. Hypertension, diabetes, high LDL-C, high apoB, and low HDL-C were all strong correlates (<.002 and="" albuminuria="" crp="" were="" also="" correlated="" with="" cvd="" after="" adjustment="" for="" age="" gender.="" carotid="" atherosclerosis="" was="" independent="" of="" other="" risk="" factors.="" conclusion:="" these="" data="" show="" high="" chd="" stroke="" prevalence="" in="" alaska="" eskimos="" despite="" low="" average="" ldl-c="" hdl-c.="" hypertension="" correlates="" identifying="" factors="" early="" treating="" to="" target="" is="" recommended.="">
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