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Association of 10-year and lifetime predicted cardiovascular disease risk with subclinical atherosclerosis in South Asians: findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study

TitleAssociation of 10-year and lifetime predicted cardiovascular disease risk with subclinical atherosclerosis in South Asians: findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study
Publication TypeJournal Article
Year of Publication2014
AuthorsKandula, NR, Kanaya, AM, Liu, K, Lee, JY, Herrington, D, Hulley, SB, Persell, SD, Lloyd-Jones, DM, Huffman, MD
JournalJ Am Heart AssocJ Am Heart Assoc
Volume3
Paginatione001117
Date PublishedOct
ISBN Number2047-9980 (Electronic)<br/>2047-9980 (Linking)
Accession Number25277669
AbstractBACKGROUND: Ten-year and lifetime cardiovascular risk assessment algorithms have been adopted into atherosclerotic cardiovascular disease (ASCVD) prevention guidelines, but these prediction models are not based on South Asian populations and may underestimate the risk in Indians, Pakistanis, Bangladeshis, Nepali, and Sri Lankans in the United States. Little is known about ASCVD risk prediction and intermediate endpoints such as subclinical atherosclerosis in US individuals of South Asian ancestry. METHODS AND RESULTS: South Asians (n=893) from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study who were 40 to 79 years and free of ASCVD were included. Ten-year ASCVD predicted risk was calculated using the 2013 Pooled Cohort Equations. Lifetime predicted risk was based on risk factor burden. Baseline levels of subclinical atherosclerosis (coronary artery calcium [CAC] and carotid intima media thickness [CIMT]) were compared across 10-year and lifetime risk strata: (1) high (>/=7.5%) 10-year and low (/=39%) lifetime and low (
Ethno Med: