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Antihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study

TitleAntihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study
Publication TypeJournal Article
Year of Publication2013
AuthorsGelber, RP, Ross, GW, Petrovitch, H, Masaki, KH, Launer, LJ, White, LR
JournalNeurologyNeurology
Volume81
Pagination888-95
Date PublishedSep 3
ISBN Number1526-632X (Electronic)<br/>0028-3878 (Linking)
Accession Number23911753
KeywordsAdrenergic beta-Antagonists/ therapeutic use, Aged, Aged, 80 and Over, Aging/drug effects/ ethnology/psychology, Antihypertensive Agents/ therapeutic use, Asia/ethnology, Asian Americans/ ethnology, Cognition Disorders/ ethnology/prevention & control/psychology, Cohort Studies, Follow-Up Studies, Hawaii/ethnology, Humans, Hypertension/drug therapy/ ethnology/psychology, Male, Prospective Studies, Risk Factors
AbstractOBJECTIVE: To determine the associations between classes of antihypertensive medication use and the risk of cognitive impairment among elderly hypertensive men. METHODS: The Honolulu-Asia Aging Study is a prospective, community-based cohort study of Japanese American men conducted in Honolulu, Hawaii. We examined 2,197 participants (mean age 77 years at cohort entry, 1991-1993, followed through September 2010) with hypertension and without dementia or cognitive impairment at baseline, who provided information on medication use. Cognitive function was assessed at 7 standardized examinations using the Cognitive Abilities Screening Instrument (CASI). Cognitive impairment was defined as a CASI score 75 years, and those with pulse pressure >/=70 mm Hg. CONCLUSIONS: beta-blocker use is associated with a lower risk of developing cognitive impairment in elderly Japanese American men.
Ethno Med: