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Albuminuria among Alaska Natives--findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study

TitleAlbuminuria among Alaska Natives--findings from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study
Publication TypeJournal Article
Year of Publication2010
AuthorsJolly, SE, Noonan, CJ, Roubideaux, YD, Goldberg, JH, Ebbesson, SO, Umans, JG, Howard, BV
JournalNephron Clin PractNephron Clin Pract
Volume115
Paginationc107-13
ISBN Number1660-2110 (Electronic)<br/>1660-2110 (Linking)
Accession Number20407273
KeywordsAdolescent, Adult, Aged, Aged, 80 and Over, Alaska/ethnology, Albuminuria/complications/ ethnology/ genetics, Coronary Artery Disease/complications/ ethnology/ genetics, Cross-Sectional Studies, Diabetes Mellitus/ethnology/genetics, Female, Humans, Hypertension/complications/ethnology/genetics, Indians, North American/ ethnology/ genetics, Male, Middle Aged, Risk Factors, Young Adult
AbstractBACKGROUND: The prevalence and associated risk factors for albuminuria and low-grade albuminuria in Alaska Natives is not known. METHODS: Cross-sectional analysis of the Genetics of Coronary Artery Disease in Alaska Natives Study. We included 1,026 individuals, who represent 85% of the study participants for whom complete data were available. Risk factors examined were age, sex, education, diabetes, hypertension, obesity, lipids, C-reactive protein, angiotensin-converting enzyme inhibitor use, and smoking status. Urine albumin excretion was estimated by the albumin/creatinine ratio measured from a single random morning urine sample. Albuminuria was defined as an albumin/creatinine ratio of > or =30 mg/g. Low-grade albuminuria was defined as an albumin/creatinine ratio of 10 to
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