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Adverse outcomes in Alaska natives who recovered from or have chronic hepatitis C infection

TitleAdverse outcomes in Alaska natives who recovered from or have chronic hepatitis C infection
Publication TypeJournal Article
Year of Publication2010
AuthorsMcMahon, BJ, Bruden, D, Bruce, MG, Livingston, S, Christensen, C, Homan, C, Hennessy, TW, Williams, J, Sullivan, D, Rosen, HR, Gretch, D
JournalGastroenterologyGastroenterology
Volume138
Pagination922-31 e1
Date PublishedMar
ISBN Number1528-0012 (Electronic)<br/>0016-5085 (Linking)
Accession Number19909749
KeywordsAdult, Age Factors, Alaska/epidemiology, Alcohol Drinking/adverse effects/ethnology, Carcinoma, Hepatocellular/ethnology/etiology, Disease Progression, Female, Genotype, Hepacivirus/genetics, Hepatitis C, Chronic/ complications/ ethnology/mortality/therapy, Humans, Incidence, Indians, North American/statistics & numerical data, Liver Diseases/ ethnology/ etiology/mortality/therapy, Liver Neoplasms/ethnology/etiology, Liver Transplantation/statistics & numerical data, Male, Middle Aged, Odds Ratio, Prospective Studies, Retrospective Studies, Risk Assessment, Risk Factors, Survival Analysis, Time Factors, Treatment Outcome
AbstractBACKGROUND & AIMS: The factors associated with adverse outcome from hepatitis C virus (HCV) infection are incompletely understood. To determine the incidence and risk factors associated with the development of end-stage liver disease (ESLD) and liver-related death (LRD), we conducted a retrospective/prospective population-based study in a cohort of Alaska Native persons chronically infected with HCV from 1994 to 2005. METHODS: We followed 960 persons prospectively for an average of 7.2 years and retrospectively for 12.1 years with data from medical records and serum samples. We compared data from subjects that were chronically infected with those who recovered from HCV infection, stratified by alcohol use. Survival models were used to examine factors associated with ESLD and LRD in chronically infected patients. RESULTS: During prospective follow-up, 80 (8.8%) and 47 (5.2%) patients developed ESLD and LRD, respectively. In examining incidence per 100 person-years, no difference was found among heavy alcohol users in the incidence of LRD (2.28 versus 3.50; P = .34) or ESLD (3.21 versus 5.69; P = .13) in persons with chronic HCV compared with those recovered from HCV infection. In subjects that consumed
Ethno Med: